Biomedical SciencesProfessorITP Graduate Coordinator

Education

Post-doc, Pathology & Immunotox. University of Pennsylvania, Philadelphia, PA. 1998

Ph.D. Pathology & Lab Med. Albany Medical College (AMC), Albany, NY. 1996

M.S. Biomedical Sciences, State University of New York / AMC, Albany, NY. 1993

M.S. Molecular Biology, Institute of Biophysics, Chinese Academy of Sci. 1991

B.S. Virology, Wuhan University, Wuhan, P.R. China. 1988

Areas of Expertise
  • Autoimmunity
  • Biomarkers
  • Cell Marker
  • Endocrinology
  • Immunotoxicology
  • Molecular Mechanisms
  • Neuroendocrinology
  • Prenatal Programming
  • Toxicology
Honors, Awards, and Achievements

Student‐selected speaker, The Interdisciplinary Environmental Toxicology program, the University of Illinois in Urbana‐Champaign (2018)

“Honorable Mention” in the 2019 Best Paper Award in Toxicological Sciences, Board of Publications, the Society of Toxicology

The 2020 Excellence in Research by Graduate Students Award in the Life Sciences from the Graduate School, UGA (Yingjia Chen)

Research Interests

(Immuno) Toxicology of nanobiomaterials and endocrine disruptors
Diabetes, prostate cancer, asthma, probiotics, microbiome
Translational study (www.devertigo.com)

Selected Publications

Xu J, Huang G, Nagy T, Teng Q, Guo TL. Sex-dependent effects of bisphenol A on type 1 diabetes development in non-obese diabetic (NOD) mice. Arch Toxicol. 2019; 93(4):997-1008. PubMed PMID: 30600366.

Huang G, Xu J, Cai D, Chen SY, Nagy T, Guo TL. Exacerbation of Type 1 Diabetes in Perinatally Genistein Exposed Female Non-Obese Diabetic (NOD) Mouse Is Associated with Alterations of Gut Microbiota and Immune Homeostasis. Toxicol Sci. 2018 Oct 1;165(2):291-301.

Chen Y, Guo TL. Dietary Early Glycation Products Promote the Growth of Prostate Tumors More than Advanced Glycation End-Products through Modulation of Macrophage Polarization. Mol Nutr Food Res. 2019;63(4):e1800885.

Feng Y, Tian J, Xie HQ, She J, Xu SL, Xu T, Tian W, Fu H, Li S, Tao W, Wang L, Chen Y, Zhang S, Zhang W, Guo TL, Zhao B. Effects of Acute Low-Dose Exposure to the Chlorinated Flame Retardant Dechlorane 602 and Th1 and Th2 Immune Responses in Adult Male Mice. Environ Health Perspect. 2016 Sep;124(9):1406-13. PubMed PMID: 27081854.

Grant Support

NIH R41, Guo (PI), 06/17-05/20

Engineering Probiotics to Biosynthesize Natural Substances for Microbiome-Brain Research

The major goal of this project is to engineer probiotics to biosynthesize 5-hydroxytryptophan (5-HTP) for microbiome-brain research. Role: PI

NIH R41, Guo (PI), 09/19-09/20

Prevention of type 1 diabetes using early glycation products

This study aims to determine the effects of EGPs generated using the spray-drying method for large-scale production on T1D development and the underlying mechanisms.

 

USDA-NIFA, Guo (co-PI), 9/2019-8/22

Effect of Nanocellulose and Food Matrix on Nutrient Absorption and Colonic Fermentation

The major goal of this project is to determine how nanocellulose affects the absorption of nutrients, and colonic fermentation of nanocellulose with Drs. Kong, Lin and Stelzleni. Role: Co-PI