Department Head, Veterinary Biosciences and Diagnostic ImagingProfessor

Education

Postdoctoral Appointment National Institute of Environmental Health Sciences

Ph.D. Toxicology, North Carolina State University

M.S. Physiology, North Carolina State University

Honors, Awards, and Achievements

NCSU-College of Veterinary Medicine Employee of the year 1986.

North Carolina State University Employee of the Year 1986.

Selected from 21 Distinguished Performance Award Recipients representing various schools and divisions of North Carolina State University.

Governor’s Award of Excellence 1987.

Selected from among all State employees for “The highest recognition that an employee can receive from State Government”. Award was in the category “Devotion to Duty”, presented by Governor James Martin on  September 8, 1987. First NCSU employee ever to receive this award.

Winning poster presentation, Immunotoxicology Section, National Society of Toxicology 1991 meetings in Dallas, TX. Title: Modulation of perinatal thymocyte cell surface antigen expression and inhibition of thymocyte maturation by prenatal exposure to tetrachlorodibenzo-p-dioxin (TCDD).

MSD AGVET Award for Creativity in Teaching 1994. Merck Foundation award for innovative approaches to veterinary medical education. Project Title: Production of a Plastinated Dog. This award included a $1000 honorarium.

MSD AGVET Award for Creativity in Teaching 1995. Merck Foundation award for innovative approaches to veterinary medical education. Project Title: A computer-based teaching aid for instruction in canine transverse-sectional anatomy and computed tomography. This award included a $1000 honorarium.

Faculty Advisor for Veterinary Class of 1998. Selected in 1995 by the students to serve as the faculty advisor for the entire class.

Recipient of the Virginia-Maryland Regional College of Veterinary Medicine Teaching Excellence Award 1995.

Recipient of the Virginia Tech Academy Award for Teaching Excellence, 1995.

Recipient of the Pfizer Animal Health Award for Research Excellence, 1996. The Pfizer Research Award is a national award that attempts to recognize research excellence in the nation’s 27 veterinary colleges. This award included a $1000 honorarium.

Faculty Advisor for Veterinary Class of 2001. Selected in 1998 by the students to serve as the faculty advisor for the entire class.

Carl J. Norden Distinguished Teaching Award, 1998. (considered to be the highest teaching award in veterinary medical education).

Awards Committee Member, American College of Toxicology 2003 (elected by membership ballot).

Invited member, The Scientific Consulting Group, Inc., Gaithersburg, MD. 1996-date.

Research Interests

Immunotoxicology

Developmental toxicology

Environmental toxicology

Selected Publications

Prater MR, Johnson VJ, Luster MI, Holladay SD. In Utero exposure to CpG ODN alters maternal
cytokine profile and fetal craniofacial and distal limb development in the C57Bl/6 mouse model.
Vaccine 24:263-272, 2006.

Prater MR, Laudermilch CL, Holladay SD. Does immune stimulation or antioxidant therapy reduce
placental damage via activation of Jak-STAT and NFkB signaling pathways? Placenta 28:566-570,
2007.

Mustafa A, Holladay SD, Goff M, Witonsky S, Kerr R, Reilly C, Sponenberg P, Gogal RM Jr. An
enhanced postnatal autoimmune profile in 24 week-old C57BL/6 mice developmentally exposed to
TCDD. Toxicology and Applied Pharmacology 232:51-59, 2008.

Gogal RM Jr, Holladay SD. Prenatal TCDD and postnatal autoimmune disease. Journal of
Immunotoxicology 5:413-408, 2008. (invited review).

Mustafa A, Holladay SD, Goff M, Witonsky S, Kerr R, Reilly C, Sponenberg P, Weinstein DA,
Karpuzoglu-Belgin E, Gogal RM Jr. Prenatal exposure to 2,3,7,8-tetrachlordibenzo-p-dioxin
(TCDD) alters adult B cell lymphopoiesis and exacerbates autoimmune lupus in 24-week-old SNF1
mice. Toxicological Sciences 112:133-143, 2009.

Holladay SD, Mustafa A, Gogal RM Jr. Prenatal TCDD in mice increases adult autoimmunity.
Reproductive Toxicology 92:82-94, 2011.

Mustafa A, Holladay SD, Witonsky S, Kerr R, Reilly C, Zimmerman K, Manari A, Countermarsh
S, Gogal RM Jr. Prenatal TCDD causes persistent modulation of the postnatal immune response,
and exacerbates inflammatory disease, in 36-week-old lupus-like autoimmune SNF1 mice. Birth
Defects Research B: Developmental and Reproductive Toxicology 92:82-94, 2011.

Mustafa A, Holladay SD, Witonsky S, Reilly C, Sponenberg DP, Gogal RM Jr. A single mid-
gestation exposure of C57BL/6 mice to TCDD causes permanent postnatal shifts toward an
autoreactive immune phenotype. Toxicology 290:157-169, 2011.

Kerr RP, Krunkosky TM, Hurley DJ, Cummings BS, Holladay SD, Gogal RM Jr. Lead induces
autophagy and aberrant MHC Class II surface expression in murine macrophage Raw 267.4 cells
by dysregulatio of MHC-II+ compartment exocytosis. Toxicology In Vitro 27:1018-1024, 2013.

Karpuzoglu E, Schimdt CW, Pardo J, Hansen M, Guo TL, Holladay SD, Gogal RM Jr. Serine
protease inhibition attenuates estrogen-mediated rIL12-induced GZMA activity and proinflammatory
biomolecules by modulating Th2 profile. Endocrinology 155:2909-2923, 2014.

Finger JW Jr, Williams RJ, Hamilton MT, Elsey RM, Oppenheimer VA, Holladay SD, Gogal RM Jr. Influence of collection time on hematologic and immune markers in the American alligator (Alligator mississippiensis). Journal of Immunoassay and Immunochemistry 36:496-509, 2015.

Clinically silent calvarial defects in a dog secondary to failure of endochondral and intramembranous ossification. Cohen EB, Sharma A, Smith B, Holladay S, Holmes SP. Jacobs Journal of Anatomy 1(1):003, 2015.

Shaikh LS, Holmes SP, Selberg KT, Jarrett C, Holladay SD, Thomason J, Coleman
Imaging diagnosis: Radiographic, ultrasonographic, computed tomographic, and

fluoroscopic appearance of a distal pelvic limb arteriovenous malformation in a young German shepherd dog. Journal of Veterinary Ultrasound and Radiology 57:16-21, 2016.

Williams RJ, Tannenbaum LV, Williams SM, Holladay SD, Tuckfield RC, Sharma A, Gogal RM. Ingestion of a single 2.3 mm lead pellet by laying Roller pigeon hens reduces egg size and adversely affects F1 generation hatchlings. Archives of Environmental Contamination and Toxicology 73:513-521, 2017.

Williams RJ, Holladay SD, Williams SM, Gogal RM Jr. Environmental lead and wild birds: A review. Reviews of Environmental Contamination and Toxicology 245:157-180, 2018.

Williams RJ, Karpuzoglu E, Connell H, Hurley DJ, Holladay SD, Gogal RM Jr. Lead alters intracellular protein signaling and suppresses pro-inflammatory activation in TLR4 and IFNR-stimulated murine RAW 264.7 cells, in vitro. Journal of Toxicology and Environmental Health, Part A. ePub March 19, 2019.

Grant Support

20+ years as PI on NIH and DoD awards

Presently co-PI on DoD SBIR for decontamination of military working dogs