Professor

Education

Doctor of Philosophy (Toxicology) – University of Georgia, 1998

Master of Science (Physiology) – University of Georgia, 1996

Bachelor of Science – Higher Inst. Zootech. & Vet. Med., Bulgaria, 1990

Honors, Awards, and Achievements

2004 – Society of Toxicology / American Chemistry Council Early Career Award

2004 – Pfizer Award for Research Excellence

2005 – Member, Sigma Xi Scientific Research Society

2005 – Honorary Member, Phi Zeta, The Honor Society of Veterinary Medicine

2005 – Fellow, Institute for Neurocognitive Science and Technology (INST)

2006 – Sigma Xi Ralph Powe Research Award

2007 – Outstanding Faculty Research Award for the College of Veterinary Medicine, Mississippi State University Office of Research and Economic Development

2008 – Member, Editorial Board of Journal of Applied Toxicology

2009 – 2012 –  Member, Editorial Board of NeuroToxicology

2011 – Member, Editorial Board of Frontiers in Toxicogenomics

2008 – Ad hoc Member of various NIH Study Sections, i.e., NAL, DBD, MD86

2013 – Associate Editor of NeuroToxicology

2013 – Member, Editorial Board of Toxicology Letters

2016 – 2020 –  Regular member of the NURE study section of the VA

2018 – Fellow, Academy of Toxicological Sciences (ATS)

2019 – Lalita and Raghubir Sharma Distinguished Professor in Toxicology, College of Veterinary Medicine, University of Georgia

2020 – Member, Editorial Board of Toxicological Sciences

2020 – Zoetis Award for Research Excellence

2020-2021 – President, Neurotoxicology Specialty Section of the Society of Toxicology

Research Interests

Neuroimmunotoxicology, Neurotoxicology, Immunotoxicology, Pesticides, Metals, Fescue Toxicosis, Environmental perturbations of the integrome

Selected Publications

Krishna, S., M. M. Keralapurath, Z. Lin#, J. J. Wagner, C. B. de La Serre, D. A. Harn, and N. M. Filipov*. (2015). Neurochemical and electrophysiological deficits in the ventral hippocampus and selective behavioral alterations caused by high-fat diet in female C57BL/6 mice. Neuroscience. 297:170-181. Epub: April 4, 2015. PMID: 25849614

Krishna, S., C. A. Dodd, and N. M. Filipov*. (2016). Behavioral and monoamine perturbations in adult male mice with chronic inflammation induced by repeated peripheral lipopolysaccharide administration. Behavioural Brain Research. 302: 279–290. Epub: January 21, 2016. PMID: 26802725

Krishna , S., Z. Lin, C. B. de La Serre, J. J. Wagner, D. A. Harn, L. M. Pepples, D. M. Djani, M. T. Weber, L. Srivastava, and N. M. Filipov*. (2016). Time-dependent behavioral, neurochemical, and metabolic dysregulation in female C57BL/6 mice caused by chronic high-fat diet intake. Physiology and Behavior. 157: 196-208. Epub: February 4, 2016, PMID: 26852949

Mote R. S., N. S. Hill, K. Uppal, V. T. Tran, D. P. Jones, N. M. Filipov*. (2017). Metabolomics of fescue toxicosis in grazing beef steers. Food and Chemical Toxicology. 105:285-299. Epub: April 18, 2017. PMID: 28428084

Pati, S., S. Krishna , J. H. Lee, M. K. Ross, C. B. de La Serre, D. A. Harn, Jr., J. J. Wagner, N. M. Filipov*, and B. S. Cummings*. (2018). Effects of high-fat diet and age on the blood lipidome and circulating endocannabinoids of female C57BL/6 mice. BBA Molecular and Cell Biology of Lipids. 1863(1):26-39. Epub: October 3, 2017. PMID: 28986283

Chen, Y., N. M. Filipov, and T. L. Guo. (2018). Dietary glycation products regulate immune homeostasis: early glycation products promote prostate cancer cell proliferation through modulating macrophages. Molecular Nutrition and Food Research. 62(3), 1700641. Epub: October 30, 2017. PMID: 29082675

Mote, R. S. , N. S. Hill, J. H. Skarlupka, Z. B. Turner, Z. P. Sanders, D. P. Jones, G. Suen, and N. M. Filipov*. (2019). Response of beef cattle fecal microbiota to grazing on toxic tall fescue grazing. (2019). Applied and Environmental Microbiology, 85 (15), pii: e00032-19. Epub: May 24, 2019. PMID: 31126949

Carpenter, J. M., H. E. Gordon, H. D. Ludwig, J. J. Wagner, D. A. Harn, T. Norberg, and N. M. Filipov*. (2019). Neurochemical and neuroinflammatory perturbations in two Gulf War Illness models: Modulation by the immunotherapeutic LNFPIII. Neurotoxicology, 77: 40-50. Epub: December 19, 2019. PMID: 31866310

Brown, K, N. M. Filipov, and J. J. Wagner. 2020.  Dorsoventral-specific effects of a sarin surrogate, diisopropylfluorophosphate, on synaptic transmission in the mouse hippocampus. Journal of Pharmacology and Experimental Therapeutics. 373(1): 10-23. Epub: January 6, 2020. PMID: 31907304

Mote, R. S. , N. S. Hill, J. H. Skarlupka, V. T. Tran, D. I. Walker,  Z. B. Turner, Z. P. Sanders, D. P. Jones, G. Suen, and N. M. Filipov*. (2020). Toxic tall fescue grazing increases susceptibility of the Angus steer fecal microbiota and plasma/urine metabolome to environmental effects. Scientific Reports, 10(1): 2497. Epub: February 12, 2020. PMID: 32051515

Fang, X., W. Sun, J. Jeon, M. Azain, H. Kinder, J. Ahn, H. C. Chung, R. S. Mote, N. M. Filipov, Q. Zhao, S. Rayalam*, and H .J. Park*. (2020). Perinatal docosahexaenoic acid supplementation improves cognition and alters brain function organization in piglets. Nutrients, Epub: XXXXX; Accepted, July 10, 2020.

Grant Support

USDA (AFRI); NIFA (2020-67015-31301); “Dysregulated microbiome, metabolome, and microbiome-metabolome interactions in beef cattle grazing toxic tall fescue”; 7/01/20- 6/30/23; Role: PI.

USDA (AFRI); NIFA (2020-67017-30839); “Assessing the effects of maternal supplementation of eggs and docosahexaenoic acid on gut microbiome and cognitive development in an infant piglet model”; 4/01/20- 3/31/22; Role: Co-I.

NIH (NIEHS); 1R21ES026383-01; “Mycobacterium tuberculosis-manganese interactions and neurotoxicity”; 5/01/16 – 4/30/21; Role: PI.

Department of Defense (CDMRP); GWI150195; “Evaluation of treatment efficacy with a potent novel immunomodulatory glycan conjugate in Gulf War Illness models”; 9/01/16 – 8/31/20; Role: PI.