Associate Professor

Education

St. Louis College of Pharmacy, 1980, BS Pharmacy

University of Washington, 1986, PhD Pharmaceutical Sciences

University of Kansas Medical Center, 1988, Post-Doctoral Fellowship, Toxicology

Honors, Awards, and Achievements

Logic Puzzles as a Predictor of Success in the PharmD Program (FP00014467)

Amer Assn Col Of Pharmacy, June 1, 2018–September 2020

Amount: $ 4,000 (US), Role: Principal investigator of, Credit: 40%

Application date: April 30, 2018, Award date: November 15, 2018, Funding type: Research

Research Interests

Brain Metabolism and Deposition as a Function of Age and Sex

Placental Transport of Drugs and Environmental Toxins

Toxicokinetics of environmental contaminants and Insecticides

Drug interactions and their influence on drug action

Selected Publications

McPhail, B.T., White, C.A., Cummings, B.S., Muralidhara, S., Wilson, J.T., and Bruckner, J.V.* (2016) The immature rat as potential model for assessing hepatotoxicity in children. Chem. Biol. Interact. 256, 167-177

Shirin Hooshfar, Tanzir Mortuza, Clinton A. Rogers, Michael R. Linzey, Darren R. Gullick, James V. Bruckner, Catherine A. White, Michael G. Bartlett. Negative chemical ionization gas chromatography– mass spectrometry of transfluthrin in rat plasma and brain. Rapid Communications in Mass Spectrometry (2017).

Amaraneni, Manoj, Jing Pang, Tanzir B. Mortuza, Srinivasa Muralidhara, Brian S. Cummings, Catherine A. White, Charles V. Vorhees, Jason Zastre, and James V. Bruckner. “Brain uptake of deltamethrin in rats as a function of plasma protein binding and blood–brain barrier maturation.” NeuroToxicology 62 (2017): 24-29.

Hooshfar, Shirin, Darren R. Gullick, Michael R. Linzey, Tanzir Mortuza, Mona Hamdy Abdel Rahman, Clinton A. Rogers, James V. Bruckner, Catherine A. White, and  Michael G. Bartlett. “Simultaneous determination of cis-permethrin and trans-permethrin in rat plasma and brain tissue using gas chromatography–negative chemical ionization mass spectrometry.” Journal of Chromatography B 1060 (2017)   291-299.

Amaraneni, Manoj, Jing Pang, James V. Bruckner, Srinivasa Muralidhara, Tanzir B. Mortuza, Darren Gullick, Shirin Hooshfar, Catherine A. White, and Brian S. Cummings. “Influence of Maturation on in Vivo Tissue to Plasma Partition Coefficients for Cis-and Trans-Permethrin.” Journal of Pharmaceutical Sciences 106 (8):2144-2151 (2017).

Mortuza, T., Edwards, G. L., White, C. A., Patel, V., Cummings, B. S., & Bruckner, J. V. (2018). Age-Dependency of Blood-Brain Barrier Penetration by cis- and trans-Permethrin in the Rat.. Drug metabolism and disposition: the biological fate of chemicals. doi:10.1124/dmd.118.084822

Mortuza, T., Muralidhara, S., White, C. A., Cummings, B. S., Hines, C., & Bruckner, J. V. (2018). Effect of dose and exposure protocol on the toxicokinetics and first-pass elimination of trichloroethylene and 1,1,1- trichloroethane. TOXICOLOGY AND APPLIED PHARMACOLOGY, 360, 185-192. doi:10.1016/j.taap.2018.09.043

Sethi, P., Bruckner, J. V., Mortuza, T. B., Cummings, B. S., Muralidhara, S., & White, C. A. (2019). Plasma Protein and Lipoprotein Binding of Cis- and Trans-Permethrin and Deltamethrin in Adult Humans and Rats. Drug Metabolism and Disposition, 47(9), 941-948. doi:10.1124/dmd.118.085464

Mortuza, T. B., Edwards, G. L., White, C. A., Patel, V., Cummings, B. S., & Bruckner, J. V. (2019). Age Dependency of Blood-Brain Barrier Penetration by cis- and trans-Permethrin in the Rat. Drug Metabolism and Disposition, 47(3), 234-237. doi:10.1124/dmd.118.084822

Song, G., Moreau, M., Efremenko, A., Lake, B. G., Wu, H., Bruckner, J. V, White CA., . . . Yoon, M. (2019). Evaluation of Age-Related Pyrethroid Pharmacokinetic Differences in Rats: Physiologically-Based Pharmacokinetic Model Development Using In Vitro Data and In Vitro to In Vivo Extrapolation. Toxicological Sciences, 169(2), 365-379. doi:10.1093/toxsci/kfz042

Pang, J., Mortuza, T., White, C. A., Muralidhara, S., Cummings, B. S., & Bruckner, J. V. (2019). Toxicokinetics of cis- and trans-Permethrin: Influence of Isomer, Maturation and Sex. Toxicological sciences : an official journal of the Society of Toxicology. doi:10.1093/toxsci/kfz237